Eminyakeni yamuva, ucwaningo onAma-Benzylamino Acids(Benzylation of Amino Acids) idonse ukunaka okusabalele. I-Benzylamino acid iyindlela yokuhlanganisa amakhemikhali, engafinyelela izinguquko zokusebenza ngokwethula amaqembu e-benzyl kuma-amino acid molecule, futhi inamathemba abanzi okusebenza. Ama-amino acid ayizisekelo eziyisisekelo zokwakha amaprotheni, futhi izakhiwo zawo nezakhiwo zibalulekile emsebenzini wamaprotheni. Ngokwethula amaqembu e-benzyl, izakhiwo ze-physicochemical zama-amino acid molecule zizoshintshwa, ngaleyo ndlela andise ukusetshenziswa kwayo emikhakheni yezokwelapha, isayensi yezinto ezibonakalayo kanye ne-organic synthesis.
Emkhakheni wezokwelapha, ucwaningo lwe-phenylmethyl amino acid lusetshenziswa kakhulu ekuhlanganiseni izidakamizwa. Ikhono layo lokwethula amaqembu e-benzyl linikeza ama-molecule ezidakamizwa ngesakhiwo esizinzile kanye nethuba lokuthuthukisa ukumuncwa kwawo. I-hydrophilicity kanye ne-lipid solubility yama-molecule ezidakamizwa kungalungiswa ngokwethula amaqembu e-benzyl, ngaleyo ndlela kuthuthukiswe umsebenzi wawo wezokwelapha kanye nokutholakala kwe-bioavailability. Lokhu kunikeza amathuba amaningi okwakhiwa kwemithi emisha futhi kukhuthaze ukuqanjwa kabusha kanye nentuthuko emkhakheni wezokwelapha. Ngaphezu kwalokho, i-phenylmethylamic acid nayo inohlu olubanzi lwezinhlelo zokusebenza ezingase zibe khona emkhakheni wesayensi yezinto.
Ngokulawula izimo ze-synthesis, izinto ze-polymer ezinemisebenzi ethile zingalungiswa. Ukwethulwa kwamaqembu e-benzyl kungalungisa umsebenzi ongaphezulu kanye nezakhiwo zemishini yezinto zokwakha, ngaleyo ndlela kuthuthukiswe ukusebenza nokusebenza kwezinto. Lokhu kunemithelela ebalulekile ekuthuthukisweni kwezinkambu ezifana nezinto zebhethri, ama-catalyst nezinzwa. Ngaphezu kwalokho, ukuthuthukiswa kwendlela ye-p-benzyl amino acid nakho kudlala indima ebalulekile ekuhlanganiseni kwe-organic. Besebenzisa le ndlela, abacwaningi bangashintsha ngokunembile ukwakheka kwama-amino acid molecule ukuze bahlanganise izinhlanganisela eziphilayo nemisebenzi ethile, njengeziphakathi zezidakamizwa nama-molecule asebenzayo. Lokhu kunikeza inkundla ebanzi ye-organic synthetic chemistry futhi ikhuthaza ukuthuthuka okuqhubekayo kwe-organic chemistry.
Njengamanje, uchungechunge lwempumelelo ebalulekile lwenziwe ocwaningweni lwe-p-phenylmethylamino acid. Ngakolunye uhlangothi, ngokwezindlela zokuhlanganisa, abacwaningi bahlala bethuthukisa izimo zokusabela kanye nezinhlelo ze-catalyst ukuze bathuthukise ukusebenza kahle kokusabela nokukhetha. Ngakolunye uhlangothi, mayelana nezinkambu zokufaka isicelo, indlela ye-phenylmethylamino acid isetshenziswe kabanzi ekutholeni izidakamizwa kanye nesayensi yezinto ezibonakalayo, futhi izuze uchungechunge lwemiphumela ebalulekile. Ngamafuphi nje, ucwaningo kanye nokusetshenziswa kwe-p-phenylmethylamino acid kuzokwenza umnikelo omuhle ekuthuthukisweni kwesayensi nobuchwepheshe. Ukusetshenziswa okusha kwale ndlela akukhuthazi nje kuphela ukuthuthukiswa komkhakha wezokwelapha, kodwa futhi kuletha impumelelo emisha kanye nezinqubo ezintsha emkhakheni wesayensi yezinto zokwakha kanye nokuhlanganiswa kwezinto eziphilayo. Kukholakala ukuthi ngemizamo yabacwaningi abaningi, ukusetshenziswa kwe-phenylmethylamino acid kuzobonisa ithemba elibanzi esikhathini esizayo.
Isikhathi sokuthumela: Aug-10-2023
