I-aminobutyric acid

I-aminobutyric acid(I-Gamma-Aminobutyric Acid, efushanisiwe njenge-GABA) iyi-amino acid ebaluleke kakhulu ekhona ebuchosheni bomuntu nezinye izinto eziphilayo. Idlala indima ye-inhibitory transmitter ohlelweni lwezinzwa, olungasiza ekulawuleni umsebenzi wesimiso sezinzwa esimaphakathi nokugcina ibhalansi yamasignali wezinzwa. Ucwaningo lweminyaka yamuva lubonise ukuthi i-GABA inezinzuzo ezihlukahlukene zempilo yomuntu, kusukela ekuthuthukiseni ikhwalithi yokulala kuya ekudambiseni ukukhathazeka, ukucindezeleka, njll, okubonisa amandla ahlaba umxhwele. Ucwaningo lwakamuva lubonise ukuthi i-GABA inomthelela omkhulu ekuthuthukiseni izinga lokulala. Ukulala kubhekwa njengenqubo yomzimba yokulungisa nokuvuselela, futhi izinga lokulala eliphansi lingaba nomthelela omubi empilweni yabantu. I-GABA ingalawula ukuqhutshwa kwezinzwa nokuvinjelwa ngokuthinta ama-GABA receptors ebuchosheni, futhi ikhuthaze ukuphumula komzimba nokulala. Ucwaningo luye lwathola ukuthi ukusebenzisa izithasiselo ze-GABA kunganciphisa kakhulu isikhathi sokulala, ukuthuthukisa ikhwalithi nobude besikhathi sokulala, futhi kunciphise inani lokuvuka ebusuku, ngaleyo ndlela kusize abantu bathole ukuphumula nokululama okungcono. Ngaphezu kwezinzuzo zayo ekuthuthukiseni ukulala, i-GABA iphinde yaboniswa ukusiza ukukhulula ukukhathazeka nokucindezeleka. Impilo enengcindezi ephezulu kanye nendawo yokusebenza esheshayo yomphakathi wanamuhla yenza abantu abaningi babhekane namazinga ahlukene okukhathazeka nokucindezeleka. I-GABA inganciphisa ukukhululwa kwe-neurotransmitter glutamate ngokusebenzisana nama-receptors e-GABA, ngaleyo ndlela yehlise ukujabula kwesimiso sezinzwa futhi ikhulule ukukhathazeka nokungezwani. Ucwaningo luye lwabonisa ukuthi ukwesekwa kwe-GABA yesikhathi eside kunganciphisa kakhulu imizwa yokukhathazeka nokucindezeleka, futhi kuthuthukise impilo yengqondo kanye nokuphila kahle. Ukwengeza, i-GABA ingasiza ukusekela ukusebenza kwengqondo kanye nempilo yobuchopho. Ubuchopho bungesinye sezitho ezibaluleke kakhulu emzimbeni womuntu futhi bubalulekile ekusebenzeni kahle kokuqonda nokucabanga. Ucwaningo luye lwathola ukuthi i-GABA ingakhuthaza umsebenzi we-GABA receptors, ithinte ukudluliselwa kwesignali nomsebenzi we-neuron ebuchosheni, ngaleyo ndlela ithuthukise ukunaka, ikhono lokufunda kanye nenkumbulo. Okutholakele kuvula amathuba amasha okubhekana nokuguga nokuvimbela izifo ezifana ne-Alzheimer's. Njengoba ucwaningo lwe-GABA luqhubeka nokujula, imikhiqizo eminingi yezempilo nokudla kwezempilo iqala ukwengeza i-GABA njengesithako esibalulekile. Kusukela kuzithasiselo zomlomo kuya eziphuzweni, ukudla, njll., uhla lokusetshenziswa kwe-GABA lukhula njalo. Kodwa-ke, abathengi badinga ukunaka ikhwalithi nomthombo wemikhiqizo lapho bethenga imikhiqizo ye-GABA, futhi bakhethe izinhlobo nemikhiqizo ethembekile. Ukusetshenziswa okubanzi kwe-GABA kuhlobene eduze nemiphumela yayo emihle kakhulu yezempilo. Ngeke nje inikeze ikhwalithi yokulala ethuthukisiwe, ikhulule ukukhathazeka nokucindezeleka, kodwa ingathuthukisa ukusebenza kobuchopho futhi ithuthukise impilo yengqondo. Ngokuzayo, ngocwaningo olujulile lwe-GABA kanye nokunaka okuqhubekayo kwabantu kwezempilo, kukholakala ukuthi i-GABA izodlala izindima zezempilo ezibaluleke kakhulu futhi isize abantu bathole izinga lempilo elingcono.